Antidepressants and anticonvulsants for neuropathic pain

Neuropathic pain is a pain syndrome that develops resulting from pathological excitation of neurons in the peripheral or central nervous system.

Typically, painkillers are used to treat neuropathic pain. If they are ineffective, patients can be prescribed with antidepressants and anticonvulsants for neuropathic pain.

Tricyclics are more often than other antidepressants used to treat pain syndrome.

Analgesic effect of drugs of this group is due to the ability to prevent:

  • reuptake of norepinephrine and serotonin;
  • impulse transmission between neurons.

The analgesic effect of tricyclic antidepressants develops within a few days; however, more time may take to achieve the desired result in some cases.

Studies have shown that Elavil, Anafranil, Vivactil, and Silenor antidepressants are effective for the treatment of neuropathic pain.

Antidepressants and anticonvulsants for neuropathic pain are a rational choice in the management of pain in patients with diabetes. Anticonvulsant drugs were originally developed as medications for epilepsy treatment.

Due to their properties, they have become widely used in the therapy of severe forms of peripheral neuropathy, including neuropathic pain.

Gabapentin is a first choice anticonvulsant for the treatment of patients with chronic neuropathic pain. The use of this drug leads to a decrease in the release of the CNS excitatory neurotransmitter glutamate and inhibition of transmission of painful impulses.

In addition, a combination of antidepressants and an anticonvulsant Pregabalin (Lyrica) is effective in the treatment of neuropathic pain. Anticonvulsants reduce the intensity of painful sensations in patients with neuropathic pain by at least two times.

The efficiency of antidepressants and anticonvulsants for neuropathic pain may differ in various patients. It is practically impossible to predict in advance whether the pain will be alleviated in a particular patient or not. Therefore, a qualified physician with experience in the therapy of neuropathic pain of a different origin should select the treatment.

In addition to reducing the pain syndrome, the combination of an antidepressant with the anticonvulsant can help normalize the patient’s affective state suffering from neuropathic pain, as well as improve night sleep.

However, the combination therapy may cause development of drowsiness and other undesirable effects in some patients. To avoid drowsiness and adverse reactions, use most of the dose before bedtime.

Antidepressants and anticonvulsants are controlled drugs and available by prescription only. You can buy antidepressants and anticonvulsants for neuropathic pain without a prescription on online pharmacy.

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